In this book, the authors suggest that a "dysmethylation syndrome" disrupts essential regulations controlling cellular growth, metabolism and mitosis, and may then cause cancer.
eBook Title: Cancer
Author:Maurice Israël,Laurent Schwartz
Published on 2005-01-01 by John Libbey Eurotext
In this book, the authors suggest that a |dysmethylation syndrome| disrupts essential regulations controlling cellular growth, metabolism and mitosis, and may then cause cancer. Dysmethylations (hyper or hypomethylations) affect not only the expression of genes controlling growth and mitosis, but also the activity of enzymes such as (PP2A) phosphatase, which is assembled after methylation. PP2A limits the action of trophic kinases activated by growth factors or by oncogenes. In neurones, the syndrome associated to a poor methylation of the phosphatase and other substrates, leads to hyperphosphorylated proteins, as found in Alzheimer's disease. Cancer, Alzheimer's disease may possibly have, like Biermer's anemia, essential links with methylation processes.
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Maurice Israël,Laurent Schwartz
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- Book was ranked at 6 by Google Books for Cancer
- Cancer published by John Libbey Eurotext since 2005-01-01 with ISBNs. The book ISBN 13 Code is 9782742005970 and ISBN 10 Code is 2742005978
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